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Who is at risk of interactions with Cenforce D ?
Who is at risk of interactions with Cenforce D ?
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kirazmattson
853 posts
Feb 01, 2026
10:12 PM
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Cenforce D is a combination medication containing Sildenafil Citrate (for erectile dysfunction) and Dapoxetine (for premature ejaculation). Because it combines two active drugs, certain groups of people are at higher risk of drug interactions or side effects. 1. People Taking Nitrates or Nitric Oxide Donors Examples: Nitroglycerin, isosorbide mononitrate, isosorbide dinitrate Risk: Severe drop in blood pressure, which can be life-threatening. Reason: Sildenafil (a PDE5 inhibitor) potentiates the blood-pressure-lowering effect of nitrates. 2. People on Certain Blood Pressure Medications Examples: Alpha-blockers (tamsulosin, doxazosin) Risk: Excessive Cenforce D (low blood pressure), dizziness, or fainting. 3. People Using SSRIs or Other Serotonergic Drugs Examples: Fluoxetine, sertraline, paroxetine Risk: Serotonin syndrome or reduced effectiveness of dapoxetine. Reason: Dapoxetine is a short-acting SSRI, so combining with other serotonergic drugs increases serotonergic effects. 4. People on CYP3A4 Inhibitors Examples: Ketoconazole, itraconazole, ritonavir, grapefruit juice Risk: Higher Sildenafil levels ? increased side effects (headache, flushing, dizziness). 5. People with Heart Problems Examples: Severe heart failure, recent heart attack, unstable angina Risk: Sildenafil can increase cardiac workload during sexual activity. Dapoxetine can affect blood pressure and heart rhythm. 6. Kidney or Liver Disease Patients Impaired clearance can lead to drug accumulation, increasing risk of dizziness, low blood pressure, or prolonged side effects.
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