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How Is Poxet 90 mg Metabolized In The Liver?
How Is Poxet 90 mg Metabolized In The Liver?
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Aug 23, 2025
7:01 AM
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Poxet 90 mg contains dapoxetine, a selective serotonin reuptake inhibitor (SSRI) used primarily to treat premature ejaculation. After oral administration, dapoxetine is absorbed into the bloodstream and undergoes metabolism mainly in the liver.
In the liver, dapoxetine is primarily metabolized by the enzyme cytochrome P450 3A4 (CYP3A4). This enzyme breaks down dapoxetine into inactive metabolites through oxidative processes, including N-dealkylation and hydroxylation. These metabolites are then further processed before being excreted from the body, mainly via urine and feces.
The liver metabolism of dapoxetine is significant because variations in CYP3A4 activity—due to genetics, liver function, or interactions with other drugs—can influence the concentration and effectiveness of Poxet. For example, substances that inhibit CYP3A4 (like certain antifungals or antibiotics) can increase dapoxetine levels, raising the risk of side effects.
Patients with liver impairment should use POXET 90 MG cautiously, as reduced liver function may slow metabolism, leading to higher blood levels of the drug. Dose adjustments or medical supervision may be necessary to avoid toxicity.
In summary, Poxet 90 mg is metabolized mainly by the liver enzyme CYP3A4 into inactive forms, with liver health and drug interactions playing important roles in its processing and safety.
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