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1-BOC Piperazine: A Key Intermediate for Pharmaceu
1-BOC Piperazine: A Key Intermediate for Pharmaceu
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lifechampharma566
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Jun 05, 2025
8:54 PM
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Introduction
1-Boc Piperazine
(tert-Butyl 4-piperazinecarboxylate) is a widely used protected amine intermediate in pharmaceutical and chemical research. The BOC (tert-butyloxycarbonyl) group acts as a protecting group on the nitrogen of the piperazine ring, enabling selective reactions and minimizing undesired side reactions during synthesis.
Chemical Identity
IUPAC Name: tert-Butyl 4-piperazinecarboxylate
Molecular Formula: C9H18N2O2
Molecular Weight: 186.25 g/mol
CAS Number: 57260-71-6
Appearance: White to off-white crystalline powder
Solubility: Soluble in common organic solvents like dichloromethane, ethanol, and DMF
Key Features
Protected Secondary Amine: Allows for stepwise synthesis in multi-step pharmaceutical processes
Stable Under Mild Conditions: The BOC group can be easily removed under acidic conditions without affecting other functional groups
Compatible with Peptide and API Synthesis
Applications of 1-BOC Piperazine
1. Pharmaceutical Intermediate
Commonly used in the synthesis of various active pharmaceutical ingredients (APIs), particularly in oncology, anti-inflammatory, and CNS drugs.
2. Custom Synthesis
Ideal building block for creating diverse heterocyclic structures in research and development laboratories.
3. Peptide Chemistry
Serves as a protected amine component in solid-phase peptide synthesis (SPPS) or solution-phase methods.
Deprotection Conditions
Reagents Used: Trifluoroacetic acid (TFA), HCl in dioxane
Conditions: Typically performed at room temperature
Product Formed: Free amine (piperazine derivative)
Storage and Handling
Store in a cool, dry place, away from moisture and direct sunlight
Use gloves and goggles when handling
Stable under ambient conditions, but recommended to avoid prolonged exposure to air
Packaging and Availability
Available in:
Laboratory Packs: 1g, 5g, 10g, 25g
Bulk Quantities: 100g, 500g, 1kg, 5kg drums
Each lot is delivered with a Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS).
Conclusion
1-BOC Piperazine is an essential protected intermediate widely applied in the synthesis of pharmaceutical compounds and advanced intermediates. Its BOC protection ensures flexibility in complex organic synthesis, making it a go-to choice for R&D and industrial scale-up.
Looking to source 1-BOC Piperazine in bulk or research quantities? Contact us for technical data, pricing, and fast global delivery.
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