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What are the mechanisms underlying the pulmonary v
What are the mechanisms underlying the pulmonary v
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cliffordfosterr
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Apr 24, 2024
2:21 AM
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What are the mechanisms underlying the pulmonary vasodilatory effects of Vigora 50 Mg?
Vigora 50 mg is a brand name for sildenafil citrate, which is a medication primarily used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). The pulmonary vasodilatory effects of sildenafil, the active ingredient in Vigora 50, are primarily attributed to its ability to inhibit the enzyme phosphodiesterase type 5 (PDE5). In the pulmonary vasculature, PDE5 is primarily found in the smooth muscle cells of the pulmonary arteries. PDE5 catalyzes the breakdown of cyclic guanosine monophosphate (cGMP), a molecule that plays a crucial role in regulating vascular tone. By inhibiting PDE5, sildenafil prolongs the action of cGMP, leading to smooth muscle relaxation and vasodilation in the pulmonary arteries. This vasodilatory effect reduces pulmonary vascular resistance, which is the primary hemodynamic abnormality in PAH. By decreasing pulmonary vascular resistance, sildenafil improves pulmonary blood flow and reduces pulmonary arterial pressure, ultimately improving symptoms and exercise capacity in patients with PAH. It's important to note that while sildenafil is effective in treating PAH, it should only be used under the supervision of a healthcare professional, as it can have significant side effects and interactions with other medications.
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