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Why does Vigora 50 Mg require sexual stimulation ?
Why does Vigora 50 Mg require sexual stimulation ?
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kirazmattson
110 posts
Mar 23, 2024
2:19 AM
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Vigora 50 mg, like other medications containing sildenafil citrate, requires sexual stimulation to be effective due to its mechanism of action. Here's how it works:
Phosphodiesterase Type 5 (PDE5) Inhibition: Sildenafil citrate, the active ingredient in Vigora 50, is a phosphodiesterase type 5 (PDE5) inhibitor. PDE5 is an enzyme found in the smooth muscle cells of blood vessels, including those in the penis. It is involved in the regulation of blood flow, particularly in the context of erectile function.
Enhanced Blood Flow to the Penis: During sexual arousal, nitric oxide (NO) is released from nerve endings in the penis. NO activates an enzyme called guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells. cGMP relaxes the smooth muscle cells, allowing blood to flow into the penile tissues and produce an erection.
Augmentation of cGMP: PDE5 normally breaks down cGMP, regulating its levels in the body. By inhibiting PDE5, sildenafil citrate prevents the breakdown of cGMP, allowing it to accumulate and exert its effects on smooth muscle relaxation and blood vessel dilation in the penis. This enhances the erectile response to sexual stimulation, leading to firmer and longer-lasting erections.
Need for Sexual Stimulation: While sildenafil citrate can facilitate the physiological processes involved in achieving an erection, it does not directly cause an erection on its own. Sexual stimulation, such as physical touch, visual stimuli, or mental arousal, is necessary to activate the release of nitric oxide and initiate the cascade of events leading to erection. Without sexual stimulation, the release of nitric oxide and subsequent activation of the cGMP pathway do not occur, and Vigora 50 mg will not produce an erection.
In summary, Vigora 50 mg requires sexual stimulation to be effective because it works by enhancing the body's natural response to sexual arousal. It facilitates the erectile process by increasing blood flow to the penis, but it does not directly induce an erection in the absence of sexual stimulation.
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mbastudyabroad
1 post
Mar 23, 2024
2:26 AM
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https://www.mbastudyabroad.com/mba-in-australia/guide-to-study-mba-in-australia-best-universities-cost-and-eligibility-requirements/
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